B cell receptor signaling pathway
| PAG Title | B cell receptor signaling pathway |
| PAG ID | WIG000489 |
| Type | P |
| Source Link |  MSigDB |
| Publication Reference | NA |
| PAG Description | B cells are an important component of adaptive immunity. They produce and secrete millions of different antibody molecules, each of which recognizes a different (foreign) antigen. The B cell receptor (BCR) is an integral membrane protein complex that is composed of two immunoglobulin (Ig) heavy chains, two Ig light chains and two heterodimers of Ig-alpha and Ig-beta. After BCR ligation by antigen, three main protein tyrosine kinases (PTKs) -the SRC-family kinase LYN, SYK and the TEC-family kinase BTK- are activated. Phosphatidylinositol 3-kinase (PI3K) and phospholipase C-gamma 2 (PLC-gamma 2) are important downstream effectors of BCR signalling. This signalling ultimately results in the expression of immediate early genes that further activate the expression of other genes involved in B cell proliferation, differentiation and Ig production as well as other processes. |
| Species | Homo sapiens |
| Quality Metric Scores | nCoCo Score: 3,836 |
| Information Content | Rich |
| Other IDs | M5436 |
| Base PAG ID | WIG000489 |
| Human Phenotyte Annotation | |
| Curator | PAGER curation team |
| Curator Contact | PAGER-contact@googlegroups.com |
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